Umbilical cord stem cell therapy appears to offer an effective treatment for autism. 

Autism is a large and increasing health problem here in the UK. Currently over 600,000 people are diagnosed with the condition and that number is increasing every year. This has a huge impact on the quality of life of suffers and their families, as 25% of people with autism will never even learn to talk and 85% will never hold down a full time job.

What is the cost of autism to the UK?

It is estimated that the cost of autism to the UK economy is approximately £32bn per year, considerably higher than cancer at £12bn, heart disease at £8bn and strokes at £5bn. And yet as a country we only spend £4m per year on autism research, as compared to cancer at £590m, heart disease at £169m and stroke at £32m. 

What is autism?

The symptoms of autism generally (but not always) become apparent in the first two years of a child’s life due to alterations in the organisation and connection of the nerve cells in the brain. This can result in a range of neurodevelopmental disorders which stereotypically show as social deficits, cognitive delays, communication difficulties and repetitive behaviours.

How is autism currently treated?

Currently autism is treated in two ways, by the prescription of psychoactive drugs or anticonvulsants and/or by educational input. Neither of these treatments have been particularly efficacious and indeed until recently there has been no known medication that relieves the core symptoms of the disorder. This is quite possibly because the cause of autism is still not fully understood.

Whilst the root cause of autism remains unclear, recent brain scans and post mortem investigations of brain tissue have pointed to the fact that immune cells called microglia are often unusually active in the brains of those suffering from autism. Microglia cells will ordinarily produce an inflammatory response designed to fight infection or repair tissue damage. However, when there is no injury or infection to respond to this same inflammation may actually harm the brain.

Stem cell therapy using cord blood may be an effective approach to treating autism!

If inflammation in the brain is one of the causes of autism, as has been mooted, then stem cells, particularly taken from cord blood or cord tissue may be able to help. It is thought that these cells could assist to reduce inflammation, improve blood and oxygen flow to the brain, repair or replace damaged neurons and stimulates improved synaptic transmission.

Recent studies support this view

2017 saw the publication of a potentially transformative study into the use of umbilical cord blood to treat children with autism at Duke University, North Carolina. This safety and limited efficacy trial demonstrated that cord blood transfusion was safe with no significant side effects and that 70% of children saw improvements in their symptoms, including behaviours, communication and socialisation, indicating for the very first time that we may be able to tackle the root causes of autism.  

Not definitive but an important step in the right direction

Whilst stem cells for autism are still a way from being standard of care, this study is a huge advancement in the possible treatment of the condition. The safety trial is now being followed up by a phase II randomised clinical trial that will focus on further demonstrating the efficacy of this treatment. It is hoped that within the next few years, umbilical cord blood will become the routine therapy for autism suffers and deliver huge improvements to quality of life. 


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